Autopsy pathology : a manual and atlas, 3rd edition / by A. Connolly, W.E. Finkbeiner, P.C. Ursell and R.L. Davis
"A mainstay for pathology residents, Autopsy Pathology is designed with a uniquely combined manual and atlas format that presents today’s most complete coverage of performing, interpreting, and reporting post-mortem examinations. This lasting and useful medical reference book offers a practical, step-by-step approach to discussing not only the basics of the specialty, but the performance of specialized autopsy procedures as well."
Biphotonics for medical applications / edited by I. Meglinski
A volume in Woodhead Publishing Series in Biomaterials
This book "presents information on the interface between laser optics and cell biology/medicine. The book discusses the development and application of photonic techniques that aid the diagnosis and therapeutics of biological tissues in both healthy and diseased states. Chapters cover the fundamental technologies used in biophotonics and a wide range of therapeutic and diagnostic applications.
- Presents information on the interface between laser optics and cell biology/medicine
- Discusses the development and application of photonic techniques which aid the diagnosis and therapeutics of biological tissues in both healthy and diseased states
- Presents the fundamental technologies used in biophotonics and a wide range of therapeutic and diagnostic applications"
Ciottone's disaster medicine, 2nd edition / by G.R. Ciottone, P.D. Biddinger, R.G. Darling, S. Fares, M.E. Keim, M.S. Molloy and S. Suner
The most comprehensive resource of its kind, Ciottone’s Disaster Medicine, 2nd Edition, thoroughly covers isolated domestic events as well as global disasters and humanitarian crises. Dr. Gregory Ciottone and more than 200 worldwide authorities share their knowledge and expertise on the preparation, assessment, and management of both natural and man-made disasters,including terrorist attacks and the threat of biological warfare. Part 1 offers an A-to-Z resource for every aspect of disaster medicine and management, while Part 2 features an exhaustive compilation of every conceivable disaster event, organized to facilitate quick reference in a real-time setting.
Clinical applications for next-generation sequencing / edited by U. Demkow and R. PloskiThe most comprehensive resource of its kind, Ciottone’s Disaster Medicine, 2nd Edition, thoroughly covers isolated domestic events as well as global disasters and humanitarian crises. Dr. Gregory Ciottone and more than 200 worldwide authorities share their knowledge and expertise on the preparation, assessment, and management of both natural and man-made disasters,including terrorist attacks and the threat of biological warfare. Part 1 offers an A-to-Z resource for every aspect of disaster medicine and management, while Part 2 features an exhaustive compilation of every conceivable disaster event, organized to facilitate quick reference in a real-time setting.
This book "provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients."The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia.
Clinical radiation oncology, 4th edition / by L.L. Gunderson and J.E. Tepper
"Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team."
Data mining for bioinformatics applications / by H. Zengyou
This book "provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation."
Early vascular aging (EVA) : new directions in cardiovascular protection / edited by P.M. Nilsson, M. Hect Olsen and S. Laurent
This book "brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures.
Essentials of 3D biofabrication and translation / by A. Atala and J.J. Yoo
This book "discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine.
Head, neck and orofacial infections : a multidisciplinary approach / by J.R. Hupp
"Use best practices in effectively treating infections of the head, neck, and orofacial complex! Head, Neck, and Orofacial Infections: A Multidisciplinary Approach is the only resource on the market with in-depth guidelines to the diagnosis and management of pathology due to severe infections. No longer do you have to search through journal articles and websites, as this comprehensive, full-color reference covers both cutting-edge and time-tested approaches to recognizing and handling infections. From well-known OMS educator James Hupp and oral surgeon Elie Ferneini, and with chapters written by expert contributors, this book is ideal for use in the classroom, as preparation for the NBDE and specialty exams, and as a clinical resource for patient care."
Human physiology, biochemistry, and basic medicine / by L.A. Cole and P.R. Kramer
This book "is a unique perspective that draws together human biology, physiology, biochemistry, nutrition, and cell biology in one comprehensive volume.
In this way, it is uniquely qualified to address the needs of the emerging field of humanology, a holistic approach to understanding the biology of humans and how they are distinguished from other animals.
Coverage starts with human anatomy and physiology and the details of the workings of all parts of the male and female body. Next, coverage of human biochemistry and how sugars, fats, and amino acids are made and digested is discussed, as is human basic medicine, covering the science of diseases and human evolution and pseudo-evolution.
The book concludes with coverage of basic human nutrition, diseases, and treatments, and contains broad coverage that will give the reader an understanding of the entire human picture.
McDonald and Avery's dentistry for the child and adolescent, 10th edition / by J.A. Dean
"You can count on McDonald: the go-to source for expert, complete coverage of oral care for infants, children, and teenagers for over half a century. McDonald and Avery’s Dentistry for the Child and Adolescent, 10th Edition discusses pediatric examination, development, morphology, eruption of the teeth, and dental caries in depth — and emphasizes prevention and the treatment of the medically compromised patient. Boasting a new design and handy Evolve site, this new edition by Jeffrey A. Dean equips you with the latest diagnostic and treatment recommendations in the fast-growing field of pediatric dentistry."
Pediatric allergy : principles and practice, 3rd edition / by D.Y.M. Leung, H. Sampson, and S.J. Szefler
"The third edition of Pediatric Allergy continues this titles steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You’ll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you’re a student, resident, pediatrician or allergist, you’ll appreciate this user-friendly and versatile source for providing optimal care!"
A practical guide to rational drug design / by S. Hongmao
"This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.
The scientist's guide to cardiac metabolism / edited by M. Schwarzer and T. Doenst
This book "combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism.This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease.
Note that you will not find the following title in the U of T library catalogue (but we are working on remedying this!):
The health of populations : beyond medicine / by J. James
This book "uses current research and in-depth analysis to provide insights into the issues and challenges of population health; a subject of increasing concern, due largely to rapid population growth, population aging, rising costs and diminishing resources, health inequality, and the global rise in noncommunicable diseases. Reducing the global burden of disease requires prevention of disease incidence, which is achievable through reduction of exposure to primary (behavioral) and secondary (biomedical) risk factors. The 15 chapters of the book are divided into three sections that focus on the science of health, the harm of medicine, and how to achieve optimal health. By highlighting the benefits of preventing incidence of disease, this book illustrates how biomedicine needs to be repositioned form being the dominant approach in healthcare to being an adjunct to behavioral, legislative, social, and other preventive means for optimizing population health.
- Fills the gap between state-of-the-art technology and evidence-based practice
- Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment
- Promotes a practical tool that clinicians can apply directly to patient care
- Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases
- Presents evidence regarding the important role of NGS in current diagnostic strategies"
Clinical radiation oncology, 4th edition / by L.L. Gunderson and J.E. Tepper
"Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team."
Data mining for bioinformatics applications / by H. Zengyou
This book "provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation."
Early vascular aging (EVA) : new directions in cardiovascular protection / edited by P.M. Nilsson, M. Hect Olsen and S. Laurent
This book "brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures.
- Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control
- Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease
- Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA
- Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness
- Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures"
Essentials of 3D biofabrication and translation / by A. Atala and J.J. Yoo
This book "discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine.
- Provides a new and versatile method to fabricating living tissue
- Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction
- Describes current approaches and future challenges for translational science
- Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms"
Head, neck and orofacial infections : a multidisciplinary approach / by J.R. Hupp
"Use best practices in effectively treating infections of the head, neck, and orofacial complex! Head, Neck, and Orofacial Infections: A Multidisciplinary Approach is the only resource on the market with in-depth guidelines to the diagnosis and management of pathology due to severe infections. No longer do you have to search through journal articles and websites, as this comprehensive, full-color reference covers both cutting-edge and time-tested approaches to recognizing and handling infections. From well-known OMS educator James Hupp and oral surgeon Elie Ferneini, and with chapters written by expert contributors, this book is ideal for use in the classroom, as preparation for the NBDE and specialty exams, and as a clinical resource for patient care."
Human physiology, biochemistry, and basic medicine / by L.A. Cole and P.R. Kramer
This book "is a unique perspective that draws together human biology, physiology, biochemistry, nutrition, and cell biology in one comprehensive volume.
In this way, it is uniquely qualified to address the needs of the emerging field of humanology, a holistic approach to understanding the biology of humans and how they are distinguished from other animals.
Coverage starts with human anatomy and physiology and the details of the workings of all parts of the male and female body. Next, coverage of human biochemistry and how sugars, fats, and amino acids are made and digested is discussed, as is human basic medicine, covering the science of diseases and human evolution and pseudo-evolution.
The book concludes with coverage of basic human nutrition, diseases, and treatments, and contains broad coverage that will give the reader an understanding of the entire human picture.
- Covers the physiology, anatomy, nutrition, biochemistry and cell biology of humans, showing how they are distinguished from other animals
- Includes medical literature and internet references, example test questions, and a list of pertinent words at the end of each chapter
- Provides unique perspective into all aspects of what makes up and controls humans"
An introduction to biotechnology : the science, technology and medical applications / by W.T. Godbey
"An Introduction to Biotechnology is a biotechnology textbook aimed at undergraduates. It covers the basics of cell biology, biochemistry and molecular biology, and introduces laboratory techniques specific to the technologies addressed in the book; it addresses specific biotechnologies at both the theoretical and application levels.
"Biotechnology is a field that encompasses both basic science and engineering. There are currently few, if any, biotechnology textbooks that adequately address both areas. Engineering books are equation-heavy and are written in a manner that is very difficult for the non-engineer to understand. Numerous other attempts to present biotechnology are written in a flowery manner with little substance. The author holds one of the first PhDs granted in both biosciences and bioengineering. He is more than an author enamoured with the wow-factor associated with biotechnology; he is a practicing researcher in gene therapy, cell/tissue engineering, and other areas and has been involved with emerging technologies for over a decade. Having made the assertion that there is no acceptable text for teaching a course to introduce biotechnology to both scientists and engineers, the author committed himself to resolving the issue by writing his own.
- The book is of interest to a wide audience because it includes the necessary background for understanding how a technology works.
- Engineering principles are addressed, but in such a way that an instructor can skip the sections without hurting course content
- The author has been involved with many biotechnologies through his own direct research experiences. The text is more than a compendium of information - it is an integrated work written by an author who has experienced first-hand the nuances associated with many of the major biotechnologies of general interest today."
This book "is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.
- Organized by species for in-depth understanding of biology, health, and best care of animals
- Features the inclusion of chinchillas, quail, and zebra finches as animal models
- Offers guidance on program and employee management
- Covers regulations, policies, and laws for laboratory animal management worldwide"
McDonald and Avery's dentistry for the child and adolescent, 10th edition / by J.A. Dean
"You can count on McDonald: the go-to source for expert, complete coverage of oral care for infants, children, and teenagers for over half a century. McDonald and Avery’s Dentistry for the Child and Adolescent, 10th Edition discusses pediatric examination, development, morphology, eruption of the teeth, and dental caries in depth — and emphasizes prevention and the treatment of the medically compromised patient. Boasting a new design and handy Evolve site, this new edition by Jeffrey A. Dean equips you with the latest diagnostic and treatment recommendations in the fast-growing field of pediatric dentistry."
The mediterranean diet : an evidence-based approach / edited by V. Preedy and R. Ross Watson
This book "offers researchers and clinicians a single authoritative source which outlines many of the complex features of the Mediterranean diet: ranging from supportive evidence and epidemiological studies, to the antioxidant properties of individual components. This book embraces a holistic approach and effectively investigates the Mediterranean diet from the cell to the nutritional well-being of geographical populations. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, endocrinology, and public health, as well as researchers, such as molecular or cellular biochemists, interested in lipids, metabolism, and obesity.
Mesenchymal stem cell derived exosomes : the potential for translational nanomedicine / by Y. Tang and B. Dawn
"Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.
Oral exams : preparing for and passing candidacy, qualifying and graduate defenses / by L.A. Foote
This book "offers researchers and clinicians a single authoritative source which outlines many of the complex features of the Mediterranean diet: ranging from supportive evidence and epidemiological studies, to the antioxidant properties of individual components. This book embraces a holistic approach and effectively investigates the Mediterranean diet from the cell to the nutritional well-being of geographical populations. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, endocrinology, and public health, as well as researchers, such as molecular or cellular biochemists, interested in lipids, metabolism, and obesity.
- Presents one comprehensive, translational source for all aspects of how the Mediterranean diet plays a role in disease prevention and health
- Experts in nutrition, diet, and endocrinology (from all areas of academic and medical research) take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches
- Features a unique section on novel nutraceuticals and edible plants used in the Mediterranean region"
Mesenchymal stem cell derived exosomes : the potential for translational nanomedicine / by Y. Tang and B. Dawn
"Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.
- Introduces the MSC-exosome mediated cell-cell communication
- Covers the major functional benefits in current MSC-derived exosome studies
- Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies"
This book "serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders.
The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease.
"Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research.
- Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders
- Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals
- Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders"
This book "focuses on magnetic resonance imaging (MRI), the imaging modality of choice for the evaluation of pituitary disorders, since it provides a detailed anatomy of the pituitary gland and surrounding structures, particularly the soft tissues. A basic understanding and interpretation of MRI is important for many clinicians outside of the field of radiology, especially endocrinologists who may receive limited formal training in such areas.
"This concise Atlas includes a brief review of the principles of magnetic resonance imaging and then reinforces these principles by utilizing a case-based approach to review various pituitary pathologies. The Atlas serves as a strong clinical teaching aid for endocrinologists, radiologists, and neurosurgeons in training. It also serves as a great reference for physicians who are currently in practice.
- Provides readers with a simple, visual approach for the evaluation of pituitary images
- Features 160 high-resolution images of the most common to the rarest of disorders affecting the pituitary
- Serves an audience of fellows, residents, and clinicians in endocrinology, radiology, neurosurgery, and anyone involved in the multidisciplinary diagnosis of pituitary disease"
"Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases."
This book "provides guidance on how to prepare for oral comprehensive and viva voce exams. Topics discussed include the supervisory committee, preparing the seminar, arranging content, mental preparation, question framing, and the types of questions to expect. At its core, the book prepares students to be the best they can be by offering insights into how to interpret and appropriately respond to explicit and implied oral comps questions. This book benefits faculty by helping them prepare new questions, also providing tips on how to mentor their students in preparation for exams. The training included can be used to prepare for intensive qualifying or certification exams, job interviews, and presentations.
- Describes in detail the general format of oral comprehensive exams, viva voce examinations and defenses, what to expect, and what the requirements are that students need to fulfill to pass.
- Includes appendices with numerous practice questions sourced from a range of disciplines and countries for individual or group learning
- Useful for Early Career academics that are supervising, supporting, and examining PhD students"
Pediatric allergy : principles and practice, 3rd edition / by D.Y.M. Leung, H. Sampson, and S.J. Szefler
"The third edition of Pediatric Allergy continues this titles steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases. You’ll have the most up-to-date research at hand thanks to an easily accessible full-color format that highlights a host of new chapters, extensive updates, and clinically focused coverage. Whether you’re a student, resident, pediatrician or allergist, you’ll appreciate this user-friendly and versatile source for providing optimal care!"
A practical guide to rational drug design / by S. Hongmao
"This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.
- Discusses various tactics applicable to daily drug design
- Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops
- Offers a unique viewpoint on drug discovery research due to the author’s cross-discipline education background
- Explores the author’s rich experiences in both pharmaceutical and academic settings"
"Perfect for radiation oncologists, medical physicists, and residents in both fields, Practical Radiation Oncology Physics provides a concise and practical summary of the current practice standards in therapeutic medical physics. A companion to the fourth edition of Clinical Radiation Oncology, by Drs. Leonard Gunderson and Joel Tepper, this indispensable guide helps you ensure a current, state-of-the art clinical practice."
This book "offers the latest information on regulations and compliance in the laboratory. With the increasing complexity of regulations and need for institutional infrastructure to deal with compliance of animal use issues, as well as a requirement surrounding human subjects, this publication provides reputable guidance and information.
The book is extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and is also a great asset for faculty or new researchers coming in to the laboratory environment. It will help prepare users for the deluge of regulatory and compliance issues they will face while conducting their scientific programs.
"The book is edited and authored by known leaders in the field of compliance and regulations, and contains extensive research on the topics. It represents the new standard for information in every laboratory.
- Provides a “one-stop" , go-to resource for the many regulatory and compliance issues that affect laboratory study and research models
- Extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and also a great asset for faculty or new researchers coming in to the laboratory environment
- Focuses on United States regulations, covering both animal models and human subjects
- Written and edited by known leaders in the field of regulatory compliance who bring many years of collective experience to the book"
The scientist's guide to cardiac metabolism / edited by M. Schwarzer and T. Doenst
This book "combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism.This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease.
- Provides a quick and comprehensive introduction into cardiac metabolism
- Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs
- Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function
- Includes historical perspectives that reference important investigators that have contributed to the development of the field"
This book "is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.
- Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials
- Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPCs, and organogenesis
- Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI
- Covers the prevailing opinions on how to harness the body’s natural repair mechanisms
- Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals"
The "updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors — Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong — head the sixth edition of this classic text, which is authored by the world’s foremost stroke experts."
Tendon Regeneration "is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.
- Provides an overview of tendon biology, disease, and tissue engineering approaches
- Presents modern, alternative approaches to developing functional tissue solutions discussed
- Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine
- Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices
- Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field"
This book "is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets.
- Provides comprehensive research on translational genomic medicine
- Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease
- Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race
- Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome"
"Trigeminocardiac Reflex is a comprehensive tutorial reference to the science, diagnosis, and possible treatment of the trigeminocardiac reflex (TCR) that is usually initiated when the trigeminal nerve is disturbed during intercranial surgery. Since first reported in 1999 by co-Editor Bernhard Schaller, the research focused on TCR is expanding. While its instance is rare, new discoveries are not only increasing diagnosis, but also providing more effective treatment protocols. This text is ideal as a reference for clinical and research neurologists, as a general introduction for clinical presentation, and as a foundation for new research.
- Represents the first tutorial reference focused on the Trigeminocardiac Reflex (TCR)
- Content organized by two of the leading scientists in the area, Dr. Tumul Chowdhury (University of Manitoba) and Prof. Bernhard Schaller (University of Southampton)
- Defines TCR, its onset, and possible treatments
- Establishes a knowledge base for the future study of the TCR and treatment protocols"
The health of populations : beyond medicine / by J. James
This book "uses current research and in-depth analysis to provide insights into the issues and challenges of population health; a subject of increasing concern, due largely to rapid population growth, population aging, rising costs and diminishing resources, health inequality, and the global rise in noncommunicable diseases. Reducing the global burden of disease requires prevention of disease incidence, which is achievable through reduction of exposure to primary (behavioral) and secondary (biomedical) risk factors. The 15 chapters of the book are divided into three sections that focus on the science of health, the harm of medicine, and how to achieve optimal health. By highlighting the benefits of preventing incidence of disease, this book illustrates how biomedicine needs to be repositioned form being the dominant approach in healthcare to being an adjunct to behavioral, legislative, social, and other preventive means for optimizing population health.
- Heavily evidence-based and thoroughly referenced with hundreds of scientific citations
- Contains a glossary, as well as valuable tables, illustrations, and information boxes to further explain core content
- Provides fresh perspectives on issues related to rapid population growth, population aging, rising costs, diminishing resources, health inequality, and more
- Carefully distils extensive tracts of information, clarifies misunderstandings, and rebuts myths with the ultimate goal of encouraging better understanding of the action needed to promote optimal health for all"